Health News

Small molecule inhibitors of SARS-CoV-2 identified by screening

Even as the vaccine rollout continues against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), seeking to bring an end to the coronavirus disease 2019 (COVID-19) pandemic, new variants emerge that show immune escape capabilities. Effective and safe drugs thus remain essential to treat severe infections with this virus. A new preprint, released on the […]

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Novel polyclonal antibody XAV-19 efficiently neutralizes UK and South African SARS-CoV-2 variants

A promising new study, released as a preprint on the bioRxiv* server, reports on the high neutralizing efficacy of a polyclonal swine antibody against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the pathogen responsible for the novel coronavirus disease 2019 (COVID-19). By demonstrating the ability of this antibody to neutralize all currently circulating viral […]

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Carpal tunnel syndrome is not just an office workers’ condition

Researchers at Henry Ford Health System have found that workers in construction and other manufacturing jobs are more susceptible for developing carpal tunnel syndrome than those who work in office jobs. In a retrospective study published in the Journal of Occupational and Environmental Medicine, researchers report that manual labor jobs that require lifting, gripping and […]

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Glycans influence SARS-CoV-2 spike–ACE2 binding affinity, finds study

A study conducted at the Los Alamos National Laboratory, USA, and Concordia University, Canada, has explored the impact of different types of glycans on the interaction between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and human angiotensin-converting enzyme 2 (ACE2) receptor. The findings reveal that although the spike – ACE2 interaction is not […]

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Researchers offer large-scale screening of potential broad-spectrum SARS-CoV-2 antivirals

The search for effective and safe antivirals against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogen responsible for the current coronavirus disease 2019 (COVID-19) pandemic assumes new urgency in the face of more virulent and transmissible variants. Apart from the development of new drugs, the repurposing of already approved drugs has been a promising […]

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Have scientists found SARS-CoV-2's Achilles' heel?

Have scientists uncovered the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Achilles’ heel? New preclinical research published in the journal Cell shows how neutralizing antibodies targeting the N-terminal domain of the coronavirus could be a potential target for antibodies to bind and effectively neutralize SARS-CoV-2. Study: N-terminal domain antigenic mapping reveals a site of vulnerability […]

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Emergence of novel SARS-CoV-2 variants and co-mutations in India

A new study has uncovered genetic changes in a group of similar severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants in India. The researchers write: "We believe that our report is one of the few studies that aim to provide a comprehensive picture of the evolutionary dynamics and co-mutations patterns of the SARS-CoV-2 strains prevalent […]