Health News

FGF23 hormone from red blood cell precursors promotes hematopoietic stem cell mobilization

A Kobe University research group including graduate student Ishii Shinichi and Associate Professor Katayama Yoshio (both of the Department of Hematology, Graduate School of Medicine) have discovered that fibroblast growth factor-23 (FGF23) produced by erythroblasts (cells that are the precursors of red blood cells) promotes the movement (mobilization) of hematopoietic stem cells into the peripheral […]

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Studies reveal mutations that boost blood stem cell growth and increase leukemia and heart disease risk

As people grow older, certain genetic mutations in hematopoietic stem cells (HSCs)—which give rise to blood and immune cells—can eventually cause cancer or predispose people to cardiovascular disease. Now, two teams of scientists at the Broad Institute of MIT and Harvard, Massachusetts General Hospital, Boston Children’s Hospital, and Dana-Farber Cancer Institute have each discovered a […]

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Researchers probe ematopoietic stem cell post-transplantation complications

Hematopoietic stem cell transplantation (HSCT) is a curative treatment for many children with both malignant and non-malignant conditions. Pericardial effusion—excess fluid around the heart—is a recognized complication following HSCT, but its incidence, risk factors and impact on mortality are not well defined. Carrie Kitko, MD, Justin Godown, MD, and colleagues used the Pediatric Health Information […]

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Scientists show MRI predicts the efficacy of a stem cell therapy for brain injury

Scientists at Sanford Burnham Prebys Medical Discovery Institute and Loma Linda University Health have demonstrated the promise of applying magnetic resonance imaging (MRI) to predict the efficacy of using human neural stem cells to treat a brain injury—a first-ever “biomarker” for regenerative medicine that could help personalize stem cell treatments for neurological disorders and improve […]