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Seizures as a main manifestation of severe pediatric SARS-CoV-2 infection

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causal agent of the coronavirus disease 2019 (COVID-19) pandemic, mostly causes symptomatic disease in adults rather than in children. In rare cases, mild COVID-19 symptoms such as headache, drowsiness, myalgia, fatigue, fever, and trivial respiratory symptoms appear in children. Study: Seizures as the main presenting manifestation of acute […]

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Increased evolutionary rates seen in SARS-CoV-2 variants of concern

An Australian study conducted at the University of Melbourne describes that the emergence of more deadly variants of concern (VOCs) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with an induction in episodic evolutionary rate. The study is currently available on the medRxiv* preprint server. Study: The emergence of SARS-CoV-2 variants of concern […]

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Study proves effectiveness of Artemisia annua against SARS-CoV-2 in vitro

A multinational research group has been the first to show the excellent activity of artemisinin-based treatment against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human cell lines – including a specific type of lung cells. Their findings were recently published in the journal Scientific Reports. Notwithstanding the increasing availability of vaccines against the […]

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Potential compounds targeting SARS-COV-2 main protease (in vivo)

The coronavirus disease 2019 (COVID-19) disease pandemic is caused by a single-stranded RNA virus, namely, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This novel coronavirus emerged in Wuhan City, China, in late December 2019. Globally, the virus is responsible for over 188 million infections and more than 4 million deaths. As a result, health officials […]

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High individual-level variability in SARS-CoV-2 shedding may explain superspreading

Researchers in the United States have provided a high-resolution description of the viral dynamics involved in acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19). The team’s daily longitudinal sampling of 60 newly infected individuals revealed that significant person-to-person variation in the shedding of infectious […]

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CRISPRa identifies potassium channels as neuronal entry factors and druggable targets for SARS-CoV-2

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes various symptoms that go beyond respiratory problems. Neurological, cardiac, and other issues can emerge during infection and after recovery in long COVID, suggesting SARS-CoV-2 invades several organs. However, how SARS-CoV-2 invades the brain — whether directly or indirectly — remains under investigation. New research led by Le […]

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Cold winter temperatures may accelerate spread of SARS-CoV-2

Researchers in China have warned that cold winter temperatures may accelerate the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and lead to new outbreaks of coronavirus disease 2019 (COVID-19). The team’s review of studies assessing the factors that affect SARS-CoV-2 survival and transmission suggested that the virus can survive on the surfaces of […]

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Repeated low-dose dose exposure to SARS-CoV-2 may protect against severe COVID-19

Emerging variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are causing a third wave in Europe, and an interesting development has been observed. As transmissible variants and vaccinations have increased, several European countries have experienced a second and third wave of the pandemic without a proportional increase in disease severity and mortality. Study: […]