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Novel polyclonal antibody XAV-19 efficiently neutralizes UK and South African SARS-CoV-2 variants

A promising new study, released as a preprint on the bioRxiv* server, reports on the high neutralizing efficacy of a polyclonal swine antibody against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the pathogen responsible for the novel coronavirus disease 2019 (COVID-19). By demonstrating the ability of this antibody to neutralize all currently circulating viral […]

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Glycans influence SARS-CoV-2 spike–ACE2 binding affinity, finds study

A study conducted at the Los Alamos National Laboratory, USA, and Concordia University, Canada, has explored the impact of different types of glycans on the interaction between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and human angiotensin-converting enzyme 2 (ACE2) receptor. The findings reveal that although the spike – ACE2 interaction is not […]

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Researchers offer large-scale screening of potential broad-spectrum SARS-CoV-2 antivirals

The search for effective and safe antivirals against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogen responsible for the current coronavirus disease 2019 (COVID-19) pandemic assumes new urgency in the face of more virulent and transmissible variants. Apart from the development of new drugs, the repurposing of already approved drugs has been a promising […]

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Have scientists found SARS-CoV-2's Achilles' heel?

Have scientists uncovered the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Achilles’ heel? New preclinical research published in the journal Cell shows how neutralizing antibodies targeting the N-terminal domain of the coronavirus could be a potential target for antibodies to bind and effectively neutralize SARS-CoV-2. Study: N-terminal domain antigenic mapping reveals a site of vulnerability […]

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Study shows how coronavirus variants spread more quickly

The fast-spreading UK, South Africa, and Brazil coronavirus variants are raising both concerns and questions about whether COVID-19 vaccines will protect against them. New work led by Bing Chen, PhD, at Boston Children's Hospital analyzed how the structure of the coronavirus spike proteins changes with the D614G mutation — carried by all three variants — […]

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New research proposes innovative antibody-based treatment to prevent SARS-CoV-2 viral entry

A brief report by researchers at the University of Virginia, USA, proposes using an antibody-based treatment with a plug-and-play strategy to inhibit the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to invade human cells. Study: An Innovative antibody-based Plug-and-Play strategy for SARS-CoV-2. Image Credit: MattLphotography / Shutterstock The spike protein of SARS-CoV-2 binds […]

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Structure and function of locked conformation of the SARS-CoV-2 spike protein identified

A new preprint research paper, posted to the bioRxiv* server, uncovered more information on the different structural conformations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The findings suggest the spike protein turns into a locked state to stabilize the spike protein during virus egress. There are three prefusion conformations for SARS-CoV-2 — two of […]

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Structure and dynamics of key receptor in migraine pain determined, paving way for better treatment options

A research team with members from Monash University, the ARC Centre for Cryo-electron Microscopy of Membrane Proteins, the University of Tokyo and the University of Otago have determined the shape and kinetics of an important cell surface (membrane) receptor called calcitonin gene-related peptide (CGRP), which has long been implicated in migraine. The work has been […]

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Nanobodies protect against SARS-CoV-2 variants in animal model

As of today, the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected more than 108 million individuals and claimed the lives of nearly 2.7 million globally. This past year management of the COVID-19 pandemic solely relied on non-pharmaceutical interventions such as school closures, physical distancing, shielding of those at heightened risk, and […]