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A personalized genomic cancer vaccine proved feasible to manufacture and was well tolerated in a phase 1 trial, according to researchers. The vaccine, PGV-001, was given to 13 patients with solid tumors or multiple myeloma who had a high risk of recurrence after surgery or autologous stem cell transplant. At last follow-up, four patients were […]
PARIS, March 31, 2021 /PRNewswire/ — The U.S. Food and Drug Administration (FDA) has approved Sarclisa (isatuximab-irfc) in combination with carfilzomib and dexamethasone (Kd), for the treatment of adult patients with relapsed or refractory multiple myeloma (RRMM) who have received one to three prior lines of therapy. “In the Phase 3 IKEMA study, the addition […]
For select older patients, it is safe to switch to a lower dose of lenalidomide maintenance therapy and discontinue dexamethasone after 9 months. The regimen is safe and yields outcomes similar to those of standard, continuous lenalidomide/dexamethasone (Rd), according to new findings. At a median follow-up of 37 months, event-free survival was 10.4 months in […]
The search for effective and safe antivirals against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogen responsible for the current coronavirus disease 2019 (COVID-19) pandemic assumes new urgency in the face of more virulent and transmissible variants. Apart from the development of new drugs, the repurposing of already approved drugs has been a promising […]