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Highly-sensitive PCR-based method to detect SARS-CoV-2 variants

A team of UK-based scientists has recently developed an allele-specific probe polymerase chain reaction method that can accurately detect different variants/lineages of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in respiratory samples. The method can detect viral variants even in samples with low viral RNA or degraded viral RNA. The study is currently available on […]

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Characterization of circulating neutrophils from hospitalized COVID-19 patients

A new preprint deals with the characterization of neutrophil phenotypes in an attempt to provide biomarkers that can predict severe disease in patients hospitalized with coronavirus disease 2019 (COVID-19). Study: Longitudinal characterization of circulating neutrophils uncovers distinct phenotypes associated with disease severity in hospitalized COVID-19 patients. Image Credit: Kateryna Kon/ Shutterstock A preprint version of […]

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Adaptive immunity in patients infected with SARS-CoV-2 Δ382 Variant

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, China in 2019 and is the causal agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic. SARS-CoV-2 is highly infectious, virulent, and has claimed more than 5 million lives worldwide. Study: Robust Virus-Specific Adaptive Immunity in COVID-19 Patients with SARS-CoV-2 Δ382 Variant […]

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Do pre-existing mental disorders and their co-occurrence affect COVID-19 clinical outcomes?

In late 2019, a novel coronavirus was detected in Wuhan, China, later called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19). On March 11, 2020, the World Health Organization declared COVID-19 a pandemic. The COVID-19 pandemic continues to mutate and evolve, causing millions of cases of mortality and morbidity worldwide. […]

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Many people's T-cells recognize the same components of SARS-CoV-2

As the current coronavirus disease-2019 (COVID-19) pandemic advances, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is mutating.  In addition to posing a significant risk of severe infection, SARS-CoV-2 variants are able to escape neutralizing antibodies induced by currently available vaccines. Scientists have proposed that complementary vaccines that can induce cytotoxic T-cell responses towards multiple […]

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The extent to which COVID-19 vaccination reduces transmission varies with vaccine type and SARS-CoV-2 strain

The coronavirus disease 2019 (COVID-19) pandemic spread worldwide in 2019, causing a global health and economic crisis. The rapid transmission of the disease combined with the high death rates in at-risk groups led to millions of deaths, and many countries introducing social distancing measures, lockdowns, and other restrictions. Study: The impact of SARS-CoV-2 vaccination on […]